Decrease of virulence for BALB/c mice produced by continuous subculturing of Nocardia brasiliensis

Decrease of virulence for BALB/c mice produced by continuous subculturing of Nocardia brasiliensis

BACKGROUND Subculturing has been extensively used to attenuate human pathogens. In this work we studied the effect of continuous subculturing of Nocardia brasiliensis HUJEG-1 on virulence in a murine model. METHODS Nocardia brasiliensis HUJEG-1 was subcultured up to 130 times on brain heart infusion over four years. BALB/c mice were inoculated in the right foot pad with the bacteria subcultur...

Decrease of Virulence for BALB / c Mice Produced 1 by Continuous Subculturing of Nocardia

SO-75R1, a new mutactimycin derivative produced by Nocardia brasiliensis.

In the course of studies on biologically active substances from pathogenic microorganisms, a new antibiotic SO-75R1 was isolated from the mycelium of Nocardia brasiliensis IFM 075. This paper describes the fermentation, isolation and structural elucidation of SO-75R1. The seed broth was prepared by inoculating mycelial elements of the producing strain (IFM 075) grown on Sabouraud dextrose agar ...

study of cohesive devices in the textbook of english for the students of apsychology by rastegarpour

this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...

Inactivation of rifampin by Nocardia brasiliensis.

Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gr...